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Numerical simulation of damage in high arch dam due to earthquake

Hong ZHONG , Gao LIN , Hongjun LI

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 3,   Pages 316-322 doi: 10.1007/s11709-009-0039-9

Abstract: the cracking evolution process and damage mode of high arch dams are studied in consideration of the heterogeneity

Keywords： mesoscopic heterogeneity     damage simulation in earthquakes     arch dam    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Data Mining for Mesoscopic Simulation of Electron Beam Selective Melting Article

Ya Qian, Wentao Yan, Feng Lin

Engineering 2019, Volume 5, Issue 4,   Pages 746-754 doi: 10.1016/j.eng.2019.06.006

Abstract: The mesoscopic modeling technique was recently introduced as a means of simulating the electron beamThis paper investigates the morphological features of the melt track from the results of mesoscopic simulationFinally, a simulation-driven optimization framework consisting of mesoscopic modeling and data mining

Keywords： Electron beam selective melting     Mesoscopic modeling     Data mining    

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bottleneck of phosphonic acid anchoring groups aiming toward enhancing the stability and efficiency of mesoscopic

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7,   Pages 1060-1078 doi: 10.1007/s11705-021-2117-z

Abstract: Novel near-infrared sensitizers with different anchoring groups aiming toward improved stability and efficiency of dye-sensitized solar cells were synthesized. Adsorption of these dyes on the mesoporous TiO2 surface revealed the dye adsorption rate of –CH=CH–COOH (SQ-139)>–CH=C(CN)COOH (SQ-140)>–PO3H2 (SQ-143)>–CH=C(CN)PO3H2 (SQ-148)>–CH=C(CN)PO3H–C2H5 (SQ-157)>–PO3H–C2H5 (SQ-151)>–CH=CH–COOH(–PO3H2) (SQ-162). The binding strength of these dyes on mesoporous TiO2 as investigated by dye desorption studies follows SQ-162>SQ-143>SQ-148>SQ-139>SQ-157~SQ-151>SQ-140 order. The acrylic acid anchoring group was demonstrated to be an optimum functional group owing to its fast dye adsorption rate and better binding strength on TiO2 along with good photoconversion efficiency. Results of dye binding on TiO2 surface demonstrated that SQ-162 bearing double anchoring groups of phosphonic and acrylic acid exhibited>550 times stronger binding as compared to dye SQ-140 having cyanoacrylic acid anchoring group. SQ-140 exhibited the best photovoltaic performance with photon harvesting mainly in the far-red to near-infrared wavelength region having short circuit current density, open-circuit voltage and fill factor of 14.28 mA·cm–2, 0.64 V and 0.65, respectively, giving the power conversion efficiency of 5.95%. Thus, dye SQ-162 not only solved the problem of very poor efficiency of dye bearing only phosphonic acid while maintaining the extremely high binding strength opening the path for the design and development of novel near-infrared dyes with improved efficiency and stability by further increasing the π-conjugation.

Keywords： anchoring groups     adsorption behaviour     dye-binding strength     squaraine dyes     dye-sensitized solar cells    

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Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 551-561 doi: 10.1007/s11684-020-0760-2

Abstract: Several studies correlated tumor recurrence with tumor heterogeneity and the immune microenvironment.this review, we introduce the different mechanisms involved in glioma progression, including tumor heterogeneity

Keywords： glioma     evolution mechanism     strategies     tumor heterogeneity     secondary glioma    

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Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 425-432 doi: 10.1007/s11684-013-0295-x

Abstract: This review briefly describes the heterogeneity of COPD, with focus on recent advances in the correlations

Keywords： chronic obstructive pulmonary disease     heterogeneity     phenotype     genotype     prediction    

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Effect of catalyst layer mesoscopic pore-morphology on cold start process of PEM fuel cells

Ahmed Mohmed DAFALLA, Fangming JIANG

Frontiers in Energy 2021, Volume 15, Issue 2,   Pages 460-472 doi: 10.1007/s11708-021-0733-4

Abstract: This work studies the effect of CCL mesoscopic pore-morphology on PEMFC cold start.

Keywords： cold start     energy conversion     fuel cells     mesoscale morphology     tortuosity     water management    

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Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 586-598 doi: 10.1007/s11709-020-0573-z

Abstract: As heterogeneity of concrete material is major concern in micromechanical-based concrete modeling, one

Keywords： concrete fracture     macroscopic     micromechanical     heterogeneity    

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Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1222-1237 doi: 10.1007/s11709-021-0773-1

Abstract: The influence of closed and open surface flaws on the stress distribution and failure in rock specimens is investigated. Heterogeneous finite element models are developed to simulate the compression tests on flawed rock specimens. The simulated specimens include those with closed flaws and those with open flaws on the surface. Systematic analyses are conducted to investigate the influences of the flaw inclination, friction coefficient and the confining stress on failure behavior. Numerical results show significant differences in the stress, displacement, and failure behavior of the closed and open flaws when they are subjected to pure compression; however, their behaviors under shear and tensile loads are similar. According to the results, when compression is the dominant mode of stress applied to the flaw surface, an open flaw may play a destressing role in the rock and relocate the stress concentration and failure zones. The presented results in this article suggest that failure at the rock surface may be managed in a favorable manner by fabricating open flaws on the rock surface. The insights gained from this research can be helpful in managing failure at the boundaries of rock structures.

Keywords： surface flaw     heterogeneity     circular hole     numerical modeling     relative displacement    

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A multiscale material model for heterogeneous liquid droplets in solid soft composites

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1292-1299 doi: 10.1007/s11709-021-0771-3

Abstract: Liquid droplets in solid soft composites have been attracting increasing attention in biological applications. In contrary with conventional composites, which are made of solid elastic inclusions, available material models for composites including liquid droplets are for highly idealized configurations and do not include all material real parameters. They are also all deterministic and do not address the uncertainties arising from droplet radius, volume fraction, dispersion and agglomeration. This research revisits the available models for liquid droplets in solid soft composites and presents a multiscale computational material model to determine their elastic moduli, considering nearly all relevant uncertainties and heterogeneities at different length scales. The effects of surface tension at droplets interface, their volume fraction, size, size polydispersity and agglomeration on elastic modulus, are considered. Different micromechanical material models are incorporated into the presented computational framework. The results clearly indicate both softening and stiffening effects of liquid droplets and show that the model can precisely predict the effective properties of liquid droplets in solid soft composites.

Keywords： liquid in solid     soft composite     computational modeling     multiscale model     heterogeneity    

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Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Frontiers of Engineering Management   Pages 550-562 doi: 10.1007/s42524-022-0193-5

Abstract: The heterogeneity of individuals can cause mask efficacy in a specific gathering environment to be differentFurthermore, the heterogeneity of gathering environments causes the epidemic prevention effect of masksGiven the heterogeneity of individual behavior, if individuals who are more active in terms of interpersonal

Keywords： COVID-19     masks     behavioral heterogeneity     asymptomatic infection    

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Mesoscopic properties of dense granular materials: An overview

Qicheng SUN, Feng JIN, Guohua ZHANG

Frontiers of Structural and Civil Engineering 2013, Volume 7, Issue 1,   Pages 1-12 doi: 10.1007/s11709-013-0184-z

Abstract: A granular material is a conglomeration of discrete solid particles. It is intrinsically athermal because its dynamics always occur far from equilibrium. In highly excited gaseous states, it can safely be assumed that only binary interactions occur and a number of kinetic theories have been successfully applied. However, for granular flows and solid-like states, the theory is still poorly understood because of the internally correlated structures, such as particle clusters and force networks. The current theory is that the mesoscale characteristics define the key differences between granular materials and homogeneous solid materials. Widespread interest in granular materials has arisen among physicists, and significant progress has been made, especially in understanding the jamming phase diagram and the characteristics of the jammed phase. In this paper, the underlying physics of the mesoscale structure is discussed in detail. A multiscale framework is then proposed for dense granular materials.

Keywords： granular matter     macroscopic structure     jamming phase transition    

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Factors affecting the distribution of microplastics in soils of China

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1710-4

Abstract:

● Microplastic (MP) abundance in soil of China was highly heterogeneous.

Keywords： Microplastic distribution     Microplastic heterogeneity     Effecting factors     Agriculture     Socio-economic    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 240-262 doi: 10.1007/s11684-022-0936-z

Abstract: Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

Keywords： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major

Jing Ma,Fei Liu,Xin Du,Duan Ma,Likuan Xiong

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 74-86 doi: 10.1007/s11684-017-0503-1

Abstract:

β-thalassemia is caused by β-globin gene mutations. However, heterogeneous phenotypes were found in individuals with same genotype, and still undescribed mechanism underlies such variation. We collected blood samples from 30 β-thalassemia major, 30 β-thalassemia minor patients, and 30 matched normal controls. Human lncRNA Array v2.0 (8 × 60 K, Arraystar) was used to detect changes in long non-coding RNAs (lncRNAs) and mRNAs in three samples each from β-thalassemia major, β-thalassemia minor, and control groups. Compared with normal controls, 1424 and 2045 lncRNAs were up- and downregulated, respectively, in β-thalassemia major patients, whereas 623 and 349 lncRNAs were up- and downregulated, respectively, in β-thalassemia minor patients. Compared with β-thalassemia minor group, 1367 and 2356 lncRNAs were up- and downregulated, respectively, in β-thalassemia major group. We selected five lncRNAs that displayed altered expressions (DQ583499, X-inactive specific transcript (Xist), lincRNA-TPM1, MRFS16P, and lincRNA-RUNX2-2) and confirmed their expression levels in all samples using real-time polymerase chain reaction. Based on coding-non-coding gene co-expression network and gene ontology biological process analyses, several signaling pathways were associated with three common organ systems exhibiting β-thalassemia phenotypes: hematologic, skeletal, and hepatic systems. This study implicates that abnormal expression levels of lncRNAs and mRNA in β-thalassemia cases may be correlated with its various clinical phenotypes.

Keywords： β-thalassemia     long non-coding RNA     mRNA     phenotypic heterogeneity     pathway    

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Title Author Date Type Operation

Numerical simulation of damage in high arch dam due to earthquake

Hong ZHONG , Gao LIN , Hongjun LI

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Data Mining for Mesoscopic Simulation of Electron Beam Selective Melting

Ya Qian, Wentao Yan, Feng Lin

Journal Article

bottleneck of phosphonic acid anchoring groups aiming toward enhancing the stability and efficiency of mesoscopic

Journal Article

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and

Zhaoshi Bao, Yongzhi Wang, Qiangwei Wang, Shengyu Fang, Xia Shan, Jiguang Wang, Tao Jiang

Journal Article

Heterogeneity of chronic obstructive pulmonary disease: from phenotype to genotype

Xu Chen, Xiaomao Xu, Fei Xiao

Journal Article

Effect of catalyst layer mesoscopic pore-morphology on cold start process of PEM fuel cells

Ahmed Mohmed DAFALLA, Fangming JIANG

Journal Article

Computational modeling of fracture in concrete: A review

Luthfi Muhammad Mauludin, Chahmi Oucif

Journal Article

Analysis of stress and failure in rock specimens with closed and open flaws on the surface

Journal Article

A multiscale material model for heterogeneous liquid droplets in solid soft composites

Journal Article

Heterogeneous influence of individuals’ behavior on mask efficacy in gathering environments

Journal Article

Mesoscopic properties of dense granular materials: An overview

Qicheng SUN, Feng JIN, Guohua ZHANG

Journal Article

Factors affecting the distribution of microplastics in soils of China

Journal Article

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

Journal Article

Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major

Jing Ma,Fei Liu,Xin Du,Duan Ma,Likuan Xiong

Journal Article